Shipping to the 🇺🇸 starting at 60 USD, and FREE shipping on orders over 150 USD!

All orders are processed in MXN, using the latest exchange rates.

Shipping to 🇺🇸 within 4-10 business days.

Your cart

Your cart is empty

Glutatión: El Zeus de los antioxidantes.

Glutathione: The Zeus of antioxidants.

Oxidative stress is a condition characterized by an imbalance between the production of reactive oxygen species ( ROS ) and the body's ability to detoxify them or repair the resulting damage. It plays a crucial role in the pathophysiology of various diseases, such as obesity, metabolic diseases, cardiovascular diseases and cancer. One of the key factors in cellular defense against oxidative stress is glutathione, a tripeptide composed of glutamate, cysteine ​​and glycine. Glutathione acts as a potent antioxidant by scavenging ROS and protecting cells from oxidative damage.

Intracellular levels of glutathione are tightly regulated and maintained through a complex network of enzymes and transporters. Glutathione synthesis occurs in two steps: the first step involves the formation of γ-glutamylcysteine ​​by the enzyme γ-glutamylcysteine ​​synthetase, and the second step involves the addition of glycine to γ-glutamylcysteine ​​by the enzyme glutathione synthetase. The rate-limiting step in glutathione synthesis is the availability of cysteine, which can be obtained from the diet or synthesized de novo from methionine.

Glutathione functions as a redox buffer, maintaining the balance between reduced glutathione (GSH) and oxidized glutathione (GSSG). The ratio of GSH to GSSG is an important indicator of cellular redox status and oxidative stress . Under conditions of oxidative stress, the GSH/GSSG ratio decreases, indicating an increased demand for glutathione to scavenge ROS. It also plays a role in xenobiotic detoxification and regulation of cellular signaling pathways .

Clinical trials have investigated the potential therapeutic effects of oral Glutathione supplementation in a variety of conditions. For example, in a study of cystic fibrosis (CF) patients, oxidative stress at the airway surface of the CF lung was found to be exacerbated by Glutathione deficiency . Furthermore, Glutathione has been studied in the context of cancer, with reports indicating a role for oxidative stress in cancer patients and the involvement of Glutathione and Glutathione-dependent enzymes in cellular defense against ROS .

Likewise, oral consumption of Glutathione has been shown to be effective in replenishing intracellular levels of the same and from this replenishment of levels, a recovery of the functions that were affected by oxidative stress can be noted, including:

  • Insulin sensitivity is restored.
  • The waste elimination process is activated through intestinal and hepatic biotransformation.
  • The functional state of previously dysfunctional biological membranes is restored by oxidation.
  • Oxidative stress markers were reduced in athletes, resulting in delayed fatigue and improved exercise performance.
  • The immune response capacity against viruses and bacteria is improved.

The effectiveness of oral glutathione is directly related to its ability to be absorbed in the digestive tract. This has historically been one of the difficulties in validating the benefits of its use. Recently, the appearance of true liposomal forms and microencapsulation technologies such as Setria have allowed us to see the true potential of oral Glutathione.

In conclusion, oxidative stress is a major factor in the development and progression of various diseases. Glutathione, through its antioxidant and detoxification properties, plays a crucial role in cellular defense against oxidative stress. Clinical trials have explored the potential benefits of oral Glutathione supplementation in diseases such as cystic fibrosis, athletic performance, and cancer. Further research is underway to fully understand the therapeutic potential and optimal dosing of oral Glutathione supplementation.


References:

Alves, A., Bassot, A., Bulteau, A., Pirola, L., & Morio, B. (2019). Glycine metabolism and its alterations in obesity and metabolic diseases. Nutrients, 11(6), 1356. https://doi.org/10.3390/nu11061356

DeLeve, L. and Kaplowitz, N. (1990). Importance and regulation of hepatic glutathione. Seminars in Liver Disease, 10(04), 251-266. https://doi.org/10.1055/s-2008-1040481

Deleve, L.D., Kaplowitz, N., 1990:November. Importance and regulation of hepatic glutathione. In Seminars in Liver Disease, Thieme Medical Publishers, Inc., 10, 4, 251—266

Dickerhof, N., Pearson, J., Hoskin, T., Berry, L., Turner, R., Sly, P., … & Cf, A. (2017). Oxidative stress in early cystic fibrosis lung disease is exacerbated by airway glutathione deficiency. Free Radical Biology and Medicine, 113, 236-243. https://doi.org/10.1016/j.freeradbiomed.2017.09.028

Didžiapetrienė, J., Kazbarienė, B., Tikuišis, R., Dulskas, A., Dabkevičienė, D., Lukosevičienė, V., … & Ostapenko, V. (2020). Oxidant/antioxidant status of breast cancer patients in pre- and post-operative periods. Medicine, 56(2), 70. https://doi.org/10.3390/medicina56020070

McLeay, Y., Stannard, S., Houltham, S., & Starck, C. (2017). Dietary thiols in exercise: oxidative stress defense, exercise performance, and adaptation. Journal of the International Society of Sports Nutrition, 14(1). https://doi.org/10.1186/s12970-017-0168-9

Miller, J., Chu, Y., Brooks, R., Richenbacher, W., Peña-Silva, R., & Heistad, D. (2008). Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. Journal of the American College of Cardiology, 52(10), 843-850. https://doi.org/10.1016/j.jacc.2008.05.043

Ochs-Balcom, H., Grant, B., Muti, P., Sempos, C., Freudenheim, J., Browne, R., … & Schünemann, H. (2005). Oxidative stress and pulmonary function in the general population. American Journal of Epidemiology, 162(12), 1137-1145. https://doi.org/10.1093/aje/kwi339

Surya, A., Liu, X., & Miller, M. (2018). Glutathione utilization in lactobacillus fermentum cect 5716. Journal of Agricultural and Food Chemistry, 66(48), 12651-12656. https://doi.org/10.1021/acs.jafc.8b06136

Zhu, S., Makosa, D., Miller, B., & Griffin, T. (2019). Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis. Connective Tissue Research, 61(1), 34-47. https://doi.org/10.1080/03008207.2019.1665035

Previous post
Next post
Purchase options
Select a purchase option to pre order this product
Countdown header
Countdown message


DAYS
:
HRS
:
MINS
:
SECS