The use of naturally occurring substances to modulate metabolic processes has been the focus of attention in the scientific community for years. Among the most promising candidates are highly specialized strains of microorganisms as well as the so-called polyphenols, widely present in nature.
This article explores the role of microbiota in metabolism and weight loss, with a specific focus on research on Bifidobacterium B420 and its effects on weight loss. It also introduces Sinetrol as one of the most studied active ingredients for stimulating lipolysis in adipocytes.
1. Microbiota and metabolism.
The human gut microbiota has attracted a great deal of attention for its profound influence on various aspects of health, including metabolism and weight control. Research has revealed the intricate relationship between gut microbiota and metabolic processes in the human body. To date, several mechanisms have been identified:
- Dietary metabolism : The gut microbiota plays a pivotal role in breaking down dietary fibre and complex carbohydrates, producing short-chain fatty acids (SCFAs) as byproducts. SCFAs have been linked to improved energy regulation and reduced fat storage(Farup and Valeur 2020) .
- Inflammation and metabolic disorders : Dysbiosis, an imbalance in the gut microbiota, can lead to chronic inflammation, which is associated with metabolic disorders such as obesity and insulin resistance(Eslick et al. 2022) .
- Energy harvesting : Certain microbes are efficient at extracting calories from food, so their absence could contribute to weight gain(Stanislawski et al. 2021) .
1.1 Microbiota and weight loss.
The impact of gut microbiota on weight loss has become an area of intense research. Studies have shown that a balanced and diverse microbiota composition can support weight loss efforts through several mechanisms:
- Appetite regulation: Microbes can influence appetite hormones, affecting hunger and satiety signals.
- Metabolic rate: A healthy microbiome can improve energy expenditure, which helps with weight loss.
- Reducing inflammation: A balanced microbiota can reduce inflammation, which is often associated with obesity.
1.2 Bifidobacterium B420 and weight loss.
Bifidobacterium B420, a specific strain of probiotic, has attracted attention for its potential role in weight control. It has been the most studied strain in relation to the effect of microbiota on metabolism and weight loss. Research papers have investigated its effects:
“Effects of Bifidobacterium B420 on weight loss”: This randomized controlled trial found that Bifidobacterium B420 supplementation led to a statistically significant reduction in body fat percentage compared to a placebo group. The probiotic appeared to modulate gut microbiota composition in favor of weight loss(Uusitupa et al. 2020) .
"Bifidobacterium B420 and appetite regulation": Another study explored the impact of Bifidobacterium B420 on appetite regulation. Participants who consumed the probiotic reported reduced feelings of hunger and cravings for high-calorie foods(Hibberd et al. 2019) .
"Bifidobacterium B420 and metabolic rate": This research demonstrated that Bifidobacterium B420 supplementation was associated with an increase in resting metabolic rate, potentially contributing to weight loss(Falcinelli et al. 2018) .
2. Sinetrol and Lipolysis.
The goal of weight loss programs is really the loss of excess body fat and the preservation of lean mass. This is why focusing on enhancing lipolysis of adipose tissue is the main objective of a body recomposition program for overweight.
Sinetrol is a proprietary blend of citrus polyphenols derived from various fruits, including oranges and grapefruit. This natural ingredient has gained attention due to its health benefits, particularly in the area of weight management and metabolic health, supported by data from clinical studies.
Its metabolic effect on fat burning has been shown to be based on:
- inhibition of phosphodiesterase (PDE) simultaneously increasing cAMP production and therefore physiological lipolysis, even at rest(Dallas et al. 2008) .
- stimulates free fatty acid metabolism through the increase of uncoupled proteins in the mitochondria (UCPs)(Cases et al. 2015) .
This ensures that both at rest and during physical activity the metabolic rate increases, leading to weight loss that can also be maintained in the long term.
Conclusion.
From all of the above it is clear that a plan focused on effectively solving body fat must include the transformation of the human microbiota towards one that is increasingly similar to the pattern presented by people with a low percentage of body fat, and for this, strains with proven clinical activity offer an indisputable advantage.
On the other hand, for the body recomposition process to occur, it is crucial to induce and stimulate the lipolytic state through various strategies, one of which is the use of polyphenols such as Sinetrol, which has been proven to have this effect.
As scientists continue to unravel the complex interactions between microbiota and metabolism, it is clear that the gut microbiome and metabolic regulation hold promise as one of the potential avenues for innovative approaches to weight management and overall well-being.
- Dr. Alejandro Espinosa Sosa founder of matterReferences :
- Cases, Julien, Cindy Romain, Constantin Dallas, Alain Gerbi, and Jean Max Rouanet. 2015. “A 12-Week Randomized Double-Blind Parallel Pilot Trial of Sinetrol XPur on Body Weight, Abdominal Fat, Waist Circumference, and Muscle Metabolism in Overweight Men.” International Journal of Food Sciences and Nutrition 66 (4): 471–77.
- Dallas, Constantin, Alain Gerbi, Guillaume Tenca, Franck Juchaux, and François-Xavier Bernard. 2008. “Lipolytic Effect of a Polyphenolic Citrus Dry Extract of Red Orange, Grapefruit, Orange (SINETROL) in Human Body Fat Adipocytes. Mechanism of Action by Inhibition of cAMP-Phosphodiesterase (PDE).” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 15 (10): 783–92.
- Eslick, Shaun, Evan J. Williams, Bronwyn S. Berthon, Timothy Wright, Constantine Karihaloo, Mark Gately, and Lisa G. Wood. 2022. “Weight Loss and Short-Chain Fatty Acids Reduce Systemic Inflammation in Monocytes and Adipose Tissue Macrophages from Obese Subjects.” Nutrients 14 (4). https://doi.org/10.3390/nu14040765 .
- Falcinelli, Silvia, Ana Rodiles, Azadeh Hatef, Simona Picchietti, Lina Cossignani, Daniel L. Merrifield, Suraj Unniappan, and Oliana Carnevali. 2018. “Influence of Probiotics Administration on Gut Microbiota Core: A Review on the Effects on Appetite Control, Glucose, and Lipid Metabolism.” Journal of Clinical Gastroenterology 52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017: S50–56.
- Farup, Per G., and Jørgen Valeur. 2020. “Changes in Faecal Short-Chain Fatty Acids after Weight-Loss Interventions in Subjects with Morbid Obesity.” Nutrients 12 (3). https://doi.org/10.3390/nu12030802 .
- Hibberd, AA, CC Yde, ML Ziegler, AH Honoré, MT Saarinen, S. Lahtinen, B. Stahl, HM Jensen, and LK Stenman. 2019. “Probiotic or Synbiotic Alters the Gut Microbiota and Metabolism in a Randomized Controlled Trial of Weight Management in Overweight Adults.” Beneficial Microbes 10 (2): 121–35.
- Stanislawski, Maggie A., Daniel N. Frank, Sarah J. Borengasser, Danielle M. Ostendorf, Diana Ir, Purevsuren Jambal, Kristen Bing, et al. 2021. “The Gut Microbiota during a Behavioral Weight Loss Intervention.” Nutrients 13 (9). https://doi.org/10.3390/nu13093248 .
- Uusitupa, Henna-Maria, Pia Rasinkangas, Markus J. Lehtinen, Sanna M. Mäkelä, Kaisa Airaksinen, Heli Anglenius, Arthur C. Ouwehand, and Johanna Maukonen. 2020. “Bifidobacterium Animalis Subsp. “Lactis 420 for Metabolic Health: Review of the Research.” Nutrients 12 (4). https://doi.org/10.3390/nu12040892 .
